Application

Loperamide hydrochloride (HCl) has been used in inflammatory pain experiments and to assess the functionality of proteins. 54

Biochem/physiol Actions

Loperamide hydrochloride (HCl) is a non-selective Ca²⁺ channel blocker. At nanomolar concentrations, it binds to µ-opioid receptors. Loperamide HCl does not cross the blood-brain barrier.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Slightly soluble in water and dilute acids, freely soluble in methanol and in chloroform, soluble in ethanol (95%).

Gene Information	human ... OPRM1(4988)
InChI key	PGYPOBZJRVSMDS-UHFFFAOYSA-N
InChI	1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H
originator	Johnson & Johnson
Quality Level	200
SMILES string	Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

Safety Data Sheet for L4762-5G

Cas Number	34552-83-5
Hazard Class	6.1
Un Number	2811
Pack Group	III

This product has met the following criteria to qualify for the following awards:

Loperamide hydrochloride,

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